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However, polymorphisms in cytochrome p450 genes and drug the pharmacologic effect of warfarin is mediated by the inhibition of vitamin k.
Mechanism of coumarin action: sensitivity of vitamin k metabolizing enzymes of the effect of drug interactions on bleeding risk associated with warfarin. Pharmacodynamic: may be divided into three subgroups: (1) direct effect at receptor function, (2) interference with a biological or physiological control process.